However, in light of the above evidence and findings of the current study, it can be inferred that in contrast to what many patients may believe, UROD itself is not the definite treatment of opiate dependency and it should be considered as a primary step in the long way of opiate dependency treatment. It means that UROD helps us to prepare patients more effectively as well as more rapidly for next steps of treatment. Following UROD by regular maintenance therapy and counseling might improve success rate of UROD in long term. However, in order to prove this hypothesis, we need further studies that compare relapse rate of UROD plus maintenance therapy and counseling with UROD alone in similar populations. In summary, although UROD by naloxone is a safe and effective method of detoxification, if it is used alone, it has a very high relapse rate in long term.
3. To shorten the time lag between a patient's last dose of opioid and his transfer (induction) onto naltrexone maintenance.
O'Connor PG, Kosten TR. Rapid and ultrarapid opioid detoxification techniques. JAMA. 1998; 279 (3) : 229 -34 [PubMed]
Rapid and Ultra-Rapid Detoxification in Adults with Opioid Addiction: A Review of Clinical and Cost-Effectiveness, Safety, and Guidelines.
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