It will also be vital that trained professionals monitor responses over the first several days because increased symptoms bring with them the potential for increased, even lethal, damage to the body if treated improperly.
Pregnant women should not be treated with chlordiazepoxide. The drug also should not be given to patients with liver failure. Because the liver's ability to oxidize substances declines before its ability to conjugate substances, medications conjugated by the liver, such as lorazepam (Ativan), oxazepam (Serax) and phenobarbital, should be used in place of chlordiazepoxide.19 Treatment regimens for these drugs are provided in Table 4 .
Concurrent treatment with traquilisers may increase the effects of relaxing the muscles – especially elderly patients receiving higher doses of Librium should be well monitored (higher risk of falling).
Elderly patients should be given a reduced dose (see section 4.2) A lower dose is also recommended for patients with chronic respiratory insufficiency due to the risk of respiratory depression. Benzodiazepines are contraindicated to treat patients with severe hepatic insufficiency as they may precipitate encephalopathy and reduced doses should be given to patients with renal or hepatic disease.
Patients should be advised that, like all medicaments of this type, Librium may modify patients' performance at skilled tasks. Sedation, amnesia, impaired concentration and impaired muscle function may adversely affect the ability to drive or use machinery. If insufficient sleep duration occurs, the likelihood of impaired alertness may be increased. Patients should further be advised that alcohol may intensify any impairment, and should, therefore, be avoided during treatment.
A significant number of alcoholics and drug abusers also have a depressive disorder or other mood or anxiety disorder.28 Treatment of these comorbid psychiatric disorders is crucial, because patients with untreated anxiety, depression or bipolar disorder frequently resume drinking alcohol or using drugs in an attempt to self-medicate their mood disorder.
Librium is excreted through milk, so breastfeeding while taking it could cause issues for the child’s health.
One of the things that make alcohol withdrawal so dangerous is that it has both psychological and physical effects. Fortunately, extensive research has been conducted around this topic, and there are a variety of medications and therapies to help alleviate symptoms.