Our brains make up only 2 percent of our bodies’ weight but use roughly 20 percent of our oxygen. Because the body spews free radicals when it uses oxygen, the brain is awash in rogue molecules. Glutathione helps protect the brain against their ravaging effects.
Finally, phenotypic approaches have been taken to study resistance to environmental or endogenous stressors that are thought to be causative agents for other diseases (e.g. cancer) using lymphocytes or fibroblasts [114-118]. This approach has the advantage that it integrates the effect of both genetic background and nutritional status of the cells in evaluating disease susceptibility. The only published study applying this approach to date in autistic disorder found that the GSH:GSSG was significantly lower in whole cell extracts and mitochondria from lymphoblastoid cells obtained from children with autistic disorder compared to controls but there was no difference in response to nitrosative stress as measured by GSH:GSSG in mitochondria .
ADI-R: Autism diagnostic interview - revised; ALAD: Delta aminolevulinic acid dehydratase; CARS: Childhood Autism Rating Scale; CNS: Central nervous system; d.f.: Degrees freedom; DSM: American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders; fGSH: Free reduced glutathione; GCL: Glutamate cysteine ligase; GCT: γ-glutamyl cyclotransferase; GGT: γ-glutamyl-transferase; GPx: Glutathione peroxidase; GSH: Reduced glutathione; GSH:GSSG: Glutathione redox ratio; GSH-R: Glutathione reductase; GS: Glutathione synthetase; GSSG: Oxidised glutathione; GST: Glutathione-S-transferases; Mg 2+ : Magnesium ions; Mn 2+ : Manganese ions; Q: Cochran's Q (a measure of statistical heterogeneity); SMD: Standardised mean difference; tGSH: Total glutathione.
Glutathione lightens the skin in healthy women. It reduces the activity of skin cells that make dark pigments (melanin). As such, glutathione may help even out the appearance of dark skin patches that appear with aging [69, 70].
I want to point out that glutathione drives the desaturase enzymes (their activity it associated with glutathione status) which means you can make more arachidonic acid. This is probably over-utilized in us. leading to more pro-inflammatory eicosanoids. This is a flu-like feeling with headaches in its full manifestation.
The same major research group published four studies showing a significant increase in plasma oxidised glutathione in autistic disorder [46-48,50] which has been replicated by a further two research groups for autism spectrum disorders [87,91] (Figure (Figure8). 8 ). Overall statistical heterogeneity was substantial (I 2 = 67%), however, there was no statistical heterogeneity between diagnostic subgroups (I 2 = 0%). Meta-analysis resulted in a SMD of 1.25 (95% CI 0.87 - 1.62) across 203 cases and 184 controls using a random effects model. As stated above, data from James et al. 2009 was not included in the analysis but is included in the tables accompanying the Figure.
Boosting glutathione and antioxidants through sulfur- and cysteine-rich foods may help maintain a healthy pregnancy. Supplements are not recommended unless prescribed by your doctor.